||Relevant Treatment Approaches
KIT V555_L576del KIT D820G KIT D820Y
gastrointestinal stromal tumor
predicted - resistant
In a clinical study, KIT D820G and KIT D820Y were identified as secondary mutations in a patient with gastrointestinal stromal tumor harboring a primary KIT V555_L576del, who developed resistance to Gleevec (imatinib mesylate) (PMID: 18488160).