||Relevant Treatment Approaches
KIT A502_Y503dup KIT N822K
gastrointestinal stromal tumor
predicted - resistant
In a clinical study, KIT N822K was identified as a secondary mutation in a patient with gastrointestinal stromal tumor harboring a primary KIT A502_Y503dup, who developed resistance to Gleevec (imatinib mesylate) (PMID: 18488160).