Molecular Profile Detail

Profile Name KIT W557_K558delinsCE KIT N822K
Gene Variant Detail

KIT N822K (gain of function)

KIT W557_K558delinsCE (gain of function - predicted)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT W557_K558delinsCE KIT N822K gastrointestinal stromal tumor predicted - resistant Imatinib Clinical Study Actionable In a clinical study, KIT N822K was identified as a secondary mutation in a patient with gastrointestinal stromal tumor harboring a primary KIT W557_K558delinsCE, who developed resistance to Gleevec (imatinib mesylate) (PMID: 18488160). 18488160
Clinical Trial Phase Therapies Title Recruitment Status