Molecular Profile Detail

Profile Name KIT V569_L576del KIT V654A KIT N822K
Gene Variant Detail

KIT N822K (gain of function)

KIT V569_L576del (gain of function - predicted)

KIT V654A (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT V569_L576del KIT V654A KIT N822K gastrointestinal stromal tumor predicted - resistant Imatinib Case Reports/Case Series Actionable In a clinical study, KIT V654A and KIT N822K were identified as secondary mutations in a patient with gastrointestinal stromal tumor harboring a primary KIT V569_L576del mutation, who developed resistance to Gleevec (imatinib) (PMID: 18488160). 18488160
Clinical Trial Phase Therapies Title Recruitment Status