||Relevant Treatment Approaches
KIT V569_L576del KIT V654A KIT N822K
gastrointestinal stromal tumor
predicted - resistant
In a clinical study, KIT V654A and KIT N822K were identified as secondary mutations in a patient with gastrointestinal stromal tumor harboring a primary KIT V569_L576del, who developed resistance to Gleevec (imatinib mesylate) (PMID: 18488160).