||Relevant Treatment Approaches
KIT Y553S KIT V556_T574del KIT D820Y
gastrointestinal stromal tumor
predicted - resistant
In a clinical study, KIT D820Y was identified as a secondary mutation in a patient with gastrointestinal stromal tumor harboring primary KIT V569_L576del and KIT Y553S mutations, who developed resistance to Gleevec (imatinib mesylate) (PMID: 18488160).