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|Profile Name||SMO T640A|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|SMO T640A||Advanced Solid Tumor||no benefit||Vismodegib||Preclinical - Cell culture||Actionable||In a preclinical study, Erivedge (vismodegib) treatment of cells expressing SMO T640A resulted in Hedgehog pathway activity similar to that of wild-type Smo in culture (PMID: 25801792).||25801792|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|