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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|AKT1 amp||Advanced Solid Tumor||predicted - sensitive||Akt Inhibitor (Pan)||ONC201||Preclinical - Cell line xenograft||Actionable||In a preclinical study, ONC201 (TIC-10) inhibited Akt activation and induced apoptosis and tumor regression in a variety of cell line xenograft models (PMID: 23390247).||23390247|
|AKT1 amp||osteosarcoma||sensitive||Akt Inhibitor (Pan)||MK2206||Preclinical - Pdx||Actionable||In a preclinical study, a patient derived xenograft (PDX) model of osteosarcoma with AKT1 amplification was sensitive to treatment with MK2206, demonstrating reduced tumor growth and increased apoptotic activity (PMID: 30266815).||30266815|