Molecular Profile Detail


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Profile Name ALK rearrange ALK V1180L ALK L1196M ALK G1202R
Gene Variant Detail

ALK G1202R (unknown)

ALK L1196M (gain of function)

ALK rearrange (unknown)

ALK V1180L (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK rearrange ALK V1180L ALK L1196M ALK G1202R lung non-small cell carcinoma predicted - resistant Brigatinib Case Reports/Case Series Actionable In a clinical case study, ALK G1202R and ALK L1196M were identified at disease progression while on Alunbrig (brigatinib) treatment in liquid biopsy of a patient with ALK-positive non-small cell lung cancer also harboring an ALK V1180L (PMID: 29935304). 29935304
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries