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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF G596R PTPN11 E76K||colorectal cancer||resistant||RMC-4550||Preclinical - Cell culture||Actionable||In a preclinical study, expression of PTPN11 E76K in colorectal cancer cells harboring BRAF G596R abolished their sensitivity to RMC-4550-induced inhibition of Erk phosphorylation and proliferation in culture (PMID: 30104724).||30104724|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|