Molecular Profile Detail


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Profile Name DNMT3A wild-type FLT3 mut NPM1 mut
Gene Variant Detail

DNMT3A wild-type (no effect)

FLT3 mutant (unknown)

NPM1 mutant (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
DNMT3A wild-type FLT3 mut NPM1 mut acute myeloid leukemia predicted - sensitive KO-539 Preclinical - Pdx Actionable In a preclinical study, KO-539 treatment prevented disease progression in patient-derived xenograft (PDX) models of DNMT3A wild-type acute myeloid leukemia harboring mutations in NPM1 and FLT3 (AACR; Mol Cancer Ther 2018;17(1 Suppl):Abstract nr LB-A27). detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries