Molecular Profile Detail

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Profile Name FGFR2 - BICC1 FGFR2 - CASP7
Gene Variant Detail

FGFR2 - BICC1 (gain of function)

FGFR2 - CASP7 (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 - BICC1 FGFR2 - CASP7 transitional cell carcinoma predicted - sensitive Erdafitinib Case Reports/Case Series Actionable In a Phase I trial, Balversa (erdafitinib) treatment resulted in partial response for more than 12 months in a urothelial cancer patient harboring FGFR2-BICC1 and FGFR2-CASP7 fusions (PMID: 26324363; NCT01703481). 26324363
Clinical Trial Phase Therapies Title Recruitment Status