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Profile Name ATM L1449*
Gene Variant Detail

ATM L1449* (loss of function - predicted)

Relevant Treatment Approaches PARP Inhibitor (Pan)

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) AsiDNA + Talazoparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA and Talzenna (talazoparib) combination treatment resulted in increased cell death and inhibition of proliferation in breast cancer cell lines compared to Talzenna (talazoparib) alone in culture (PMID: 27559053). 27559053
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) CYT01B + Talazoparib Preclinical - Cell culture Actionable In a preclinical study, CYT01B and Talzenna (talazoparib) synergistically inhibited growth of tumor cell lines in culture (AACR Annual Meeting 2019, Abstract 363). detail...
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) SN-38 + Talazoparib Preclinical - Cell culture Actionable In a preclinical study, Ewing sarcoma cells treated with SN-38 combined with Talazoparib (BMN-673) resulted in synergism, demonstrating reduced cell viability in culture (PMID: 26438158). 26438158
Unknown unknown lung small cell carcinoma not applicable PARP Inhibitor (Pan) Talazoparib Phase I Actionable In a Phase I trial, Talazoparib (BMN-673) treatment in patients with lung small cell carcinoma resulted in an objective response rate of 9% (2/23), including two patients with a partial response, and four patients with stable disease for at least 16 weeks (PMID: 28242752). 28242752
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) Talazoparib Preclinical - Cell line xenograft Actionable In a preclinical study, the Talazoparib (BMN-673) selective PARP1/2 inhibitor demonstrated antitumor activity on a variety of cell lines and xenografts with defects in DNA repair (PMID: 23881923). 23881923
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) Talazoparib Phase I Actionable In a Phase I trial, Talazoparib (BMN-673) treatment in patients with Ewing sarcoma did not result in any objective responses, however, resulted in a clinical benefit rate of 23% (PMID: 28242752). 28242752
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) Talazoparib + Temozolomide Preclinical - Cell culture Actionable In a preclinical study, Ewing sarcoma cells treated with Temodar (temozolomide) combined with Talazoparib (BMN-673) resulted in strong synergism, demonstrating decreased cell viability in culture (PMID: 26438158). 26438158
Unknown unknown prostate cancer not applicable PARP Inhibitor (Pan) Abiraterone + Prednisone + Veliparib Phase II Actionable In a Phase II (NCI 9012) trial, addition of Veliparib (ABT-888) to Zytiga (abiraterone) and Prednisone did not improve PSA response rate (72.4% vs 63.9%, p=0.27), measurable disease response rate (52.2% vs 45.0%, p=0.51), or median progression-free survival (10.1 vs 11.0 months, p=0.99) in patients with metastatic castration-resistant prostate cancer (PMID: 29261439; NCT01576172). 29261439
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) AsiDNA + Veliparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA and Veliparib (ABT-888) combination treatment resulted in increased cell death and inhibition of proliferation in breast cancer cell lines compared to Veliparib (ABT-888) alone in culture (PMID: 27559053). 27559053
Unknown unknown multiple myeloma not applicable PARP Inhibitor (Pan) B02 + Veliparib Preclinical - Cell culture Actionable In a preclinical study, the addition of B02 resulted in increased sensitivity to Veliparib (ABT-888), in a multiple myeloma cell line in culture, leading decreased cell viability (PMID: 26719576). 26719576
Unknown unknown non-Hodgkin lymphoma not applicable PARP Inhibitor (Pan) Bendamustine + Rituximab + Veliparib Phase I Actionable In a Phase I trial, seven patients with non-Hodgkin lymphoma treated with a combination of Veliparib (ABT-888), Bendamustine, and Rituxan (rituximab) demonstrated an overall response rate of 86% (6/7) and a complete response rate of 71% (5/7), and a progression free survival of 14.2 months (PMID: 28314788; NCT01326702). 28314788
Unknown unknown follicular lymphoma not applicable PARP Inhibitor (Pan) Bendamustine + Rituximab + Veliparib Phase I Actionable In a Phase I trial, five patients with follicular lymphoma treated with a combination of Bendamustine, Rituxan (rituximab), and Veliparib (ABT-888) demonstrated a complete response (PMID: 28314788; NCT01326702). 28314788
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) Bendamustine + Veliparib Phase I Actionable In a Phase I trial, the combination of Bendamustine and Veliparib (ABT-888) resulted in stable disease in 63% (12/19) of patients with advanced solid tumors (PMID: 28314788; NCT01326702). 28314788
Unknown unknown follicular lymphoma not applicable PARP Inhibitor (Pan) Bendamustine + Veliparib Phase I Actionable In a Phase I trial, a patient with follicular lymphoma treated with a combination of Veliparib (ABT-888) and Bendamustine demonstrated a complete response (PMID: 28314788; NCT01326702). 28314788
Unknown unknown lymphoma not applicable PARP Inhibitor (Pan) Bendamustine + Veliparib Phase I Actionable In a Phase I trial, seven patients with lymphoma treated with a combination of Veliparib (ABT-888) and Bendamustine demonstrated an overall response rate of 71% (5/7) and complete response rate of 57% (4/7) and progression free survival of 6.9 months (PMID: 28314788; NCT01326702). 28314788
Unknown unknown multiple myeloma not applicable PARP Inhibitor (Pan) Bendamustine + Veliparib Phase I Actionable In a Phase I trial, a patient with multiple myeloma demonstrated a partial response when treated with a combination of Bendamustine and Veliparib (ABT-888) (PMID: 28314788; NCT01326702). 28314788
Unknown unknown lung non-small cell carcinoma not applicable PARP Inhibitor (Pan) Carboplatin + Paclitaxel + Veliparib Phase II Actionable In a Phase II trial, the combination of Veliparib (ABT-888) with Paraplatin (carboplatin) and Taxol (paclitaxel) resulted in both an improved median PFS (5.8 mo vs 4.2 mo) and median OS (11.7 mo vs 9.1 mo) compared to placebo plus Paraplatin (carboplatin) and Taxol (paclitaxel) in patients with non-small cell lung carcinoma (PMID: 27803064). 27803064
Unknown unknown acute myeloid leukemia not applicable PARP Inhibitor (Pan) Carboplatin + Topotecan + Veliparib Phase I Actionable In a Phase I trial, the combination of Hycamtin (topotecan), Paraplatin (carboplatin), and Veliparib (ABT-888) resulted in a response rate of 25% (19/77) in patients with acute myeloid leukemia (PMID: 27551000). 27551000
Unknown unknown leukemia not applicable PARP Inhibitor (Pan) Carboplatin + Topotecan + Veliparib Phase I Actionable In a Phase I trial, the combination of Hycamtin (topotecan), Paraplatin (carboplatin), and Veliparib (ABT-888) resulted in an overall response rate of 33% (33/99) in leukemia patients and a response rate of 64% (14/22) in patients with aggressive myeloproliferative neoplasms or chronic myelomonocytic leukemia (PMID: 27551000). 27551000
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) Carboplatin + Veliparib Phase I Actionable In a Phase I clinical trial, the combination of Veliparib (ABT-888) and Paraplatin (carboplatin) demonstrated preliminary efficacy in patients with metastatic breast cancer, with 18.6 % (9/43) achieving partial response and 48.8% (21/43) achieving stable disease (J Clin Oncol. 2014;32(suppl):abstr 1074). detail...
Unknown unknown Her2-receptor negative breast cancer not applicable PARP Inhibitor (Pan) Cisplatin + Veliparib + Vinorelbine Phase I Actionable In a Phase I trial, Veliparib (ABT-888) in combination with Platinol (cisplatin) and Navelbine (vinorelbine) resulted in a complete response in 4% (2/48), partial response in 31% (15/48), and stable disease in 44% (31/48) of patients with Erbb2 (Her2) negative breast cancer (PMID: 26801247). 26801247
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) CYT01B + Veliparib Preclinical - Cell culture Actionable In a preclinical study, CYT01B and Veliparib (ABT-888) synergistically inhibited growth of tumor cell lines in culture (AACR Annual Meeting 2019, Abstract 363). detail...
Unknown unknown multiple myeloma not applicable PARP Inhibitor (Pan) Dinaciclib + Veliparib Preclinical - Cell line xenograft Actionable In a preclinical study, the combination of Veliparib (ABT-888) and Dinaciclib (SCH 727965) had a synergistic effect on decreasing survival of multiple myeloma cell lines in culture, and resulted in delayed tumor growth and improved survival of multiple myeloma cell line xenograft models compared to either agent alone (PMID: 26719576). 26719576
Unknown unknown pancreatic ductal adenocarcinoma not applicable PARP Inhibitor (Pan) Fluorouracil + Oxaliplatin + Veliparib Phase Ib/II Actionable In a Phase I/II trial, Veliparib (ABT-888) in combination with Adrucil (fluorouracil) and Eloxatin (oxaliplatin) demonstrated safety, and resulted in an objective response rate of 26% (15/58, 4 complete responses, 11 partial responses), a disease control rate of 52%, a progression-free survival of 4.0 months, and an overall survival of 7.8 months in patients with metastatic pancreatic ductal adenocarcinoma (PMID: 32669374; NCT01489865). 32669374
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) Irinotecan + Veliparib Phase I Actionable In a Phase I trial, Veliparib (ABT-888) and Camptosar (irinotecan) combination therapy resulted in partial response in 19% (6/31) and stable disease in 42% (13/31) of patients with advanced solid tumors (PMID: 26842236). 26842236
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) Irinotecan + Veliparib Phase I Actionable In a Phase I trial, Veliparib (ABT-888) and Camptosar (irinotecan) combination therapy resulted in partial response in 33% (3/9) of patients with advanced breast cancer (PMID: 26842236). 26842236
Unknown unknown colon cancer not applicable PARP Inhibitor (Pan) Irinotecan + Veliparib Phase I Actionable In a Phase I trial, Veliparib (ABT-888) and Camptosar (irinotecan) combination therapy resulted in partial response in 50% (2/4) of patients with colon cancer (PMID: 26842236). 26842236
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) SN-38 + Veliparib Preclinical Actionable In a preclinical study, Ewing sarcoma cells treated with SN-38 combined with Veliparib (ABT-888) resulted in synergism, demonstrating reduced cell viability in culture (PMID: 26438158). 26438158
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) Temozolomide + Veliparib Preclinical Actionable In a preclinical study, Ewing sarcoma cells treated with Temodar (temozolomide) combined with Veliparib (ABT-888) resulted in strong synergism, demonstrating reduced cell viability in culture (PMID: 26438158). 26438158
Unknown unknown ovarian carcinoma not applicable PARP Inhibitor (Pan) Topotecan + Veliparib Phase I Actionable In a Phase I trial, the combination of Veliparib (ABT-888) and topotecan demonstrated safety and tolerability, and resulted in an objective response rate of 9% (4/45; 1 complete response and 3 partial responses) and stable disease in 21 patients with ovarian carcinoma (PMID: 29138343; NCT01012817). 29138343
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) Topotecan + Veliparib Phase I Actionable In a Phase I trial, the combination of Veliparib (ABT-888) and topotecan demonstrated safety and tolerability, and resulted in an objective response rate of 10% (5/51; 1 complete response and 4 partial responses) and stable disease for at least 4 months in 43% (22/51) of patients with advanced solid tumors, with the majority of the patients having ovarian, fallopian tube, or primary peritoneal cancer (PMID: 29138343; NCT01012817). 29138343
Unknown unknown astrocytoma no benefit PARP Inhibitor (Pan) Veliparib Preclinical - Cell culture Actionable In a preclinical study, Veliparib (ABT-888) had a very limited effect on the cell viability of multiple cultured pediatric high grade astrocytoma cell lines (PMID: 26351319). 26351319
Unknown unknown brain stem glioma no benefit PARP Inhibitor (Pan) Veliparib Preclinical - Cell culture Actionable In a preclinical study, Veliparib (ABT-888) had a very limited effect on the cell viability of multiple cultured pediatric diffuse intrinsic pontine glioma cell lines (PMID: 26351319). 26351319
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) BGP-15 Preclinical - Cell culture Actionable In a preclinical study, BGP-15 induced apoptosis and inhibited growth of breast cancer cells in culture (PMID: 22661288). 22661288
Unknown unknown prostate cancer not applicable PARP Inhibitor (Pan) BGP-15 Preclinical - Cell culture Actionable In a preclinical study, BGP-15 induced apoptosis and inhibited growth of prostate cancer cells in culture (PMID: 22661288). 22661288
Unknown unknown colon cancer not applicable PARP Inhibitor (Pan) BGP-15 Preclinical - Cell line xenograft Actionable In a preclinical study, BGP-15 induced apoptosis and inhibited growth of colon cancer cells in culture and in cell line xenograft models (PMID: 22661288). 22661288
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) AsiDNA + Rucaparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA and Rubraca (rucaparib) combination treatment resulted in increased cell death and inhibition of proliferation in breast cancer cell lines compared to Rubraca (rucaparib) alone in culture (PMID: 27559053). 27559053
Unknown unknown colorectal cancer not applicable PARP Inhibitor (Pan) CCT241533 + Rucaparib Preclinical - Cell culture Actionable In a preclinical study, CCT241533 enhanced the growth inhibition effect of Rubraca (rucaparib) in colorectal cancer cells in culture (PMID: 21239475). 21239475
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) CYT01B + Rucaparib Preclinical - Cell culture Actionable In a preclinical study, CYT01B and Rubraca (rucaparib) synergistically inhibited growth of tumor cell lines in culture (AACR Annual Meeting 2019, Abstract 363). detail...
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) NU6027 + Rucaparib Preclinical - Cell culture Actionable In a preclinical study, NU6027 enhanced the efficacy of Rubraca (rucaparib) in breast cancer cells in culture, resulting in a greater decreased cell survival (PMID: 21730979). 21730979
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) Rucaparib FDA approved Actionable In a Phase III trial that supported FDA approval, Rubraca (rucaparib) maintenance therapy significantly improved median progression-free survival compared to placebo (10.8 vs 5.4 mo, HR=0.36, p<0.0001) in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who responded to platinum-based therapy (PMID: 28916367; NCT01968213). 28916367
Unknown unknown ovarian carcinoma not applicable PARP Inhibitor (Pan) Rucaparib Phase II Actionable In a Phase II trial, Rubraca (rucaparib) demonstrated activity in patients with platinum-sensitive high-grade ovarian carcinoma, with patients in the BRCA mutant and BRCA wild-type with high genomic loss-of-heterozygosity subgroups demonstrating increased progression-free survival compared to the BRCA wild-type with low genomic loss-of-heterozygosity subgroup (PMID: 27908594). 27908594
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) Rucaparib Phase I Actionable In a Phase I trial, Rubraca (rucaparib) was well-tolerated and demonstrated preliminary efficacy, with a disease control rate of 86% (6/7), in patients with advanced solid tumors (J Clin Oncol 31, 2013 (suppl; abstr 2585)). detail...
Unknown unknown colorectal cancer not applicable PARP Inhibitor (Pan) Rucaparib + Temozolomide Preclinical - Cell line xenograft Actionable In a preclinical trial, Rubraca (rucaparib) sensitized colorectal cancer cell lines to Temodar (temozolomide) treatment both in culture and in cell line xenograft models (PMID: 17363489). 17363489
Unknown unknown triple-receptor negative breast cancer not applicable PARP Inhibitor (Pan) Fluzoparib Preclinical - Cell culture Actionable In a preclinical study, Fluzoparib inhibited DNA-damage-induced PARylation in breast cancer cell lines in culture, however, the cells demonstrated resistance to Fluzoparib treatment (PMID: 30949414). 30949414
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) Fluzoparib Preclinical - Cell culture Actionable In a preclinical study, Fluzoparib inhibited DNA-damage-induced PARylation in high-grade serous ovarian cancer cell lines in culture, however, the cells demonstrated resistance to Fluzoparib treatment (PMID: 30949414). 30949414
Unknown unknown female reproductive organ cancer not applicable PARP Inhibitor (Pan) Pamiparib Phase I Actionable In a Phase I trial, Pamiparib (BGB-290) treatment resulted in objective response in 43% (10/23) of patients with gynecological cancer (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 368PD; NCT02361723). detail...
Unknown unknown uterine cancer not applicable PARP Inhibitor (Pan) Pamiparib + Tislelizumab Case Reports/Case Series Actionable In a Phase Ib trial, the combination therapy of Tislelizumab (BGB-A317) and Pamiparib (BGB-290) resulted in a partial response in a patient with uterine cancer (J Clin Oncol 35, 2017 (suppl; abstr 3013)). detail...
Unknown unknown pancreatic cancer not applicable PARP Inhibitor (Pan) Pamiparib + Tislelizumab Case Reports/Case Series Actionable In a Phase Ib trial, the combination therapy of of Tislelizumab (BGB-A317) and Pamiparib (BGB-290) in patients with pancreatic cancer resulted in one partial response and stable disease for greater than 6 months in two patients (J Clin Oncol 35, 2017 (suppl; abstr 3013)). detail...
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) Pamiparib + Tislelizumab Phase Ib/II Actionable In a Phase Ib trial, the combination therapy of Tislelizumab (BGB-A317) and Pamiparib (BGB-290) in patients with advanced solid tumors resulted in 7 patients with a partial response, one patient with a complete response, and 6 patients experiencing stable disease for greater than 6 months (J Clin Oncol 35, 2017 (suppl; abstr 3013)). detail...
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) Pamiparib + Tislelizumab Case Reports/Case Series Actionable In a Phase Ib trial, the combination therapy of Tislelizumab (BGB-A317) and Pamiparib (BGB-290) in ovarian cancer patients resulted in 1 complete response and 5 partial responses (J Clin Oncol 35, 2017 (suppl; abstr 3013)). detail...
Unknown unknown lung non-small cell carcinoma not applicable PARP Inhibitor (Pan) Cisplatin + PJ34 Preclinical - Cell culture Actionable In a preclinical study, the combination of Platinol (cisplatin) and PJ34 worked synergistically to induce cell death in non-small cell lung carcinoma cells in culture (PMID: 23428903). 23428903
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) PJ34 Preclinical - Cell culture Actionable In a preclinical study, PJ34 induced cell cycle arrest in a variety of tumor cell lines in culture (PMID: 21840268). 21840268
Unknown unknown glioblastoma multiforme not applicable PARP Inhibitor (Pan) A-966492 + Radiotherapy + Topotecan Preclinical - Cell culture Actionable In a preclinical study, the combination treatment of A-966492 and Hycamtin (topotecan) resulted in enhanced radiosensitivity in glioblastoma cells in culture, demonstrating a greater reduction in cell survival (PMID: 28797568). 28797568
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) AsiDNA + Niraparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA and Zejula (niraparib) combination treatment resulted in increased cell death and inhibition of proliferation in breast cancer cell lines compared to Zejula (niraparib) alone in culture (PMID: 27559053). 27559053
Unknown unknown ovary epithelial cancer not applicable PARP Inhibitor (Pan) Bevacizumab + Niraparib Phase I Actionable In a Phase I trial, Avastin (bevacizumab) and Zejula (niraparib) combination treatment resulted in complete response in 8% (1/12), partial response in 33% (4/12), and a disease control rate of 91% in platinum-sensitive ovarian cancer patients (J Clin Oncol 34, 2016 (suppl; abstr 5555)). detail...
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) CYT01B + Niraparib Preclinical - Cell culture Actionable In a preclinical study, CYT01B and Zejula (niraparib) synergistically inhibited growth of tumor cell lines in culture (AACR Annual Meeting 2019, Abstract 363). detail...
Unknown unknown ovary epithelial cancer not applicable PARP Inhibitor (Pan) Niraparib FDA approved Actionable In a Phase III trial (PRIMA) that supported FDA approval, maintenance therapy with Zejula (niraparib) significantly improved progression-free survival compared to placebo in homologous-recombination deficient (21.9 vs 10.4 months, HR=0.43, p<0.001) and the overall (13.8 vs 8.2 months, HR=0.62, p<0.001) populations of patients with newly diagnosed advanced epithelial ovarian, fallopian tube, and primary peritoneal cancer who had a response to platinum-based chemotherapy (PMID: 31562799; NCT02655016). 31562799 detail...
Unknown unknown ovary epithelial cancer not applicable PARP Inhibitor (Pan) Niraparib FDA approved Actionable In a Phase III trial (NOVA) that supported FDA approval, maintenance therapy with Zejula (niraparib) improved median progression-free survival compared to placebo in germline BRCA mutant (21.0 vs. 5.5 mo., HR=0.27) and germline BRCA wild-type (9.3 vs. 3.9 mo, HR=0.45) patients with recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer, who had a complete or partial response to 2 or more prior platinum therapies (PMID: 27717299; NCT01847274). detail... 27717299
Unknown unknown prostate cancer not applicable PARP Inhibitor (Pan) Niraparib Phase I Actionable In a Phase I trial, Zejula (niraparib) treatment resulted in stable diseases with a median duration of 254 days in 43% (9/21) of patients with castration-resistant prostate cancer (PMID: 23810788; NCT00749502). 23810788
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) Niraparib Phase I Actionable In a Phase I clinical trial, Zejula (niraparib) demonstrated safety and preliminary efficacy, resulted in a durable partial response (PR) in 67% (2/3) of patients with plantinum-sensitive high-grade serous ovarian cancer, PR in 16% (3/19) and stable disease over 120 days in 16% (3/19) of patients with plantinum-resistant high-grade serous ovarian cancer (PMID: 23810788; NCT00749502) 23810788
Unknown unknown astrocytoma not applicable PARP Inhibitor (Pan) Niraparib Preclinical - Cell line xenograft Actionable In a preclinical study, pediatric high grade astrocytoma cell lines treated with Zejula (niraparib) demonstrated decreased cell viability and proliferation in culture, and a small survival benefit in xenograft models (PMID: 26351319). 26351319
Unknown unknown astrocytoma not applicable PARP Inhibitor (Pan) Niraparib + Radiotherapy Preclinical - Cell line xenograft Actionable In a preclinical study, a pediatric high grade astrocytoma cell line treated with a combination of ionizing radiation and Zejula (niraparib) demonstrated a greater reduction in cell survival in culture and a better survival benefit in xenograft models compared to either agent alone (PMID: 26351319). 26351319
Unknown unknown brain stem glioma not applicable PARP Inhibitor (Pan) Niraparib + Radiotherapy Preclinical - Cell culture Actionable In a preclinical study, a diffuse intrinsic pontine glioma cell line treated with a combination of ionizing radiation and Zejula (niraparib) in culture demonstrated a greater reduction in cell survival compared to either agent alone (PMID: 26351319). 26351319
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) Niraparib + SN-38 Preclinical - Cell culture Actionable In a preclinical study, treatment with SN-38 combined with Zejula (niraparib) demonstrated synergism in Ewing sarcoma cells in culture, resulting in reduced cell viability (PMID: 26438158). 26438158
Unknown unknown triple-receptor negative breast cancer not applicable PARP Inhibitor (Pan) Niraparib + SY-1365 Preclinical - Cell culture Actionable In a preclinical study, SY-1365 and Zejula (niraparib) synergistically induced apoptosis in triple-receptor negative breast cancer cells in culture (Proceedings of the AACR, Vol 58, April 2017, Abstract # 1151). detail...
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) Niraparib + Temozolomide Preclinical - Cell culture Actionable In a preclinical study, treatment with Temodar (temozolomide) combined with Zejula (niraparib) demonstrated strong synergism in Ewing sarcoma cells in culture, resulting in decreased cell viability (PMID: 26438158). 26438158
Unknown unknown prostate cancer not applicable PARP Inhibitor (Pan) Abiraterone + Olaparib Phase II Actionable In a Phase II trial, treatment with the combination of Lynparza (olaparib) and Zytiga (abiraterone) resulted in a prolonged median radiographic progression-free survival of 13.8 months, compared to 8.2 months with placebo plus Zytiga (abiraterone), in patients with metastatic castration-resistant prostate cancer (PMID: 29880291; NCT01972217). 29880291
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) Adavosertib + Olaparib Phase Ib/II Actionable In a Phase Ib trial, Adavosertib (MK-1775) and Lynparza (olaparib) combination therapy resulted in partial response in 17% (1/6) and stable disease in 67% (4/6) of patients with advanced solid tumors (J Clin Oncol 34, 2016 (suppl; abstr 5562)). detail...
Unknown unknown ovary epithelial cancer not applicable PARP Inhibitor (Pan) Alpelisib + Olaparib Phase I Actionable In a Phase Ib trial, Alpelisib (BYL719) and Lynparza (olaparib) combination therapy demonstrated safety and preliminary efficacy, resulted in partial response in 36% (10/28) and stable disease in 50% (14/28) of patients with epithelial ovarian cancer, overall response rate was similar for germline BRCA mutated and wild-type patients (30%, 3/10 vs 35%, 6/17, p=0.42) (PMID: 30880072; NCT01623349). 30880072
Unknown unknown glioblastoma multiforme not applicable PARP Inhibitor (Pan) AsiDNA + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA treatment led to increased sensitivity to Lynparza (olaparib), resulting in decreased survival of glioblastoma cell lines in culture (PMID: 27559053). 27559053
Unknown unknown colon cancer not applicable PARP Inhibitor (Pan) AsiDNA + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA treatment led to increased sensitivity to Lynparza (olaparib), resulting in decreased survival in colon cancer cell lines in culture (PMID: 27559053). 27559053
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) AsiDNA + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA treatment resulted in increased sensitivity to Lynparza (olaparib), inhibiting DNA repair and cell proliferation, and inducing death in breast cancer cell lines in culture (PMID: 27559053). 27559053
Unknown unknown melanoma not applicable PARP Inhibitor (Pan) AsiDNA + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA treatment led to increased sensitivity to Lynparza (olaparib), resulting in decreased survival of melanoma cell lines in culture (PMID: 27559053). 27559053
Unknown unknown cervical cancer not applicable PARP Inhibitor (Pan) AsiDNA + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA treatment led to increased sensitivity to Lynparza (olaparib), resulting in decreased survival in a cervical cancer cell line in culture (PMID: 27559053). 27559053
Unknown unknown head and neck cancer not applicable PARP Inhibitor (Pan) AsiDNA + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA treatment led to increased sensitivity to Lynparza (olaparib), resulting in decreased survival of a head and neck cancer cell line in culture (PMID: 27559053). 27559053
Unknown unknown hematologic cancer not applicable PARP Inhibitor (Pan) AsiDNA + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AsiDNA treatment sensitized hematologic cancer cell lines to Lynparza (olaparib), inhibiting survival in culture (PMID: 27559053). 27559053
Unknown unknown head and neck cancer not applicable PARP Inhibitor (Pan) AZD7648 + Olaparib Preclinical - Pdx Actionable In a preclinical study, AZD7648 and Lynparza (olaparib) combination treatment inhibited tumor growth in a patient-derived xenograft (PDX) model of head and neck cancer harboring mutant TP53 and wild-type ATM (PMID: 31699977). 31699977
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) AZD7648 + Olaparib Preclinical - Cell culture Actionable In a preclinical study, AZD7648 and Lynparza (olaparib) combination treatment inhibited viability of ovarian cancer cell lines harboring wild-type ATM in culture (PMID: 31699977). 31699977
Unknown unknown triple-receptor negative breast cancer not applicable PARP Inhibitor (Pan) Capivasertib + Olaparib Phase I Actionable In a Phase I trial, the combination of AZD5363 and Lynparza (olaparib) was well-tolerated and demonstrated preliminary activity in patients with endometrial, ovarian, or triple-negative breast cancer (TNBC), with an overall response rate of 24% (7/30; all partial responses, 1 ovarian, 4 endometrial, and 2 TNBC) and stable disease for greater than 4 months in 6 additional patients (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #391P; NCT02208375). detail...
Unknown unknown endometrial cancer not applicable PARP Inhibitor (Pan) Capivasertib + Olaparib Phase I Actionable In a Phase I trial, the combination of AZD5363 and Lynparza (olaparib) was well-tolerated and demonstrated preliminary activity in patients with endometrial, ovarian, or triple-negative breast cancer (TNBC), with an overall response rate of 24% (7/30; all partial responses, 1 ovarian, 4 endometrial, and 2 TNBC) and stable disease for greater than 4 months in 6 additional patients, and a response rate of 50% (4/8) in endometrial cancer patients (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #391P; NCT02208375). detail...
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) Capivasertib + Olaparib Phase I Actionable In a Phase I trial, Capivasertib (AZD5363) and Lynparza (olaparib) combination therapy was well-tolerated, and resulted in a clinical benefit rate of 44.6% (25/56, 14 partial responses, 11 stable disease >= 4 months) in patients with advanced solid tumors (PMID: 32532747; NCT02338622). 32532747
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) Capivasertib + Olaparib Phase I Actionable In a Phase I trial, the combination of AZD5363 and Lynparza (olaparib) was well-tolerated and demonstrated preliminary activity in patients with endometrial, ovarian, or triple-negative breast cancer (TNBC), with an overall response rate of 24% (7/30; all partial responses, 1 ovarian, 4 endometrial, and 2 TNBC) and stable disease for greater than 4 months in 6 additional patients (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #391P; NCT02208375). detail...
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) CCT241533 + Olaparib Preclinical - Cell culture Actionable In a preclinical study, CCT241533 enhanced the growth inhibition effects of Lynparza (olaparib) in cancer cells in culture (PMID: 21239475). 21239475
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) Cediranib + Durvalumab + Olaparib Phase I Actionable In a Phase I trial, the combination of Cediranib (AZD-2171), Imfinzi (durvalumab), and Lynparza (olaparib) treatment demonstrated tolerability and activity in female patients with ovarian, endometrial, or triple-negative breast cancer, with a response rate of 33% (3/9; 2 pts with ovarian cancer, and 1 pt with endometrial cancer), and stable disease in 4/9 pts (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #390P; NCT02484404). detail...
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) Cediranib + Olaparib Phase I Actionable In a Phase I clinical trial, the combination therapy of Cediranib (AZD-2171) and Lynparza (olaparib) demonstrated safety and efficacy in patients with ovarian cancer (J Clin Oncol 32:5s, 2014 (suppl; abstr LBA5500)). detail...
Unknown unknown oral squamous cell carcinoma not applicable PARP Inhibitor (Pan) Cisplatin + Olaparib Preclinical - Cell line xenograft Actionable In a preclinical study, treatment of oral squamous carcinoma cells with Platinol (cisplatin) and Lynparza (olaparib) resulted in a synergistic effect demonstrating increased apoptosis and tumor growth inhibition in culture and cell line xenograft models (PMID: 26927065). 26927065
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) CYT01B + Olaparib Preclinical - Cell culture Actionable In a preclinical study, CYT01B and Lynparza (olaparib) synergistically inhibited growth of tumor cell lines in culture (AACR Annual Meeting 2019, Abstract 363). detail...
Unknown unknown prostate cancer not applicable PARP Inhibitor (Pan) Durvalumab + Olaparib Phase II Actionable In a Phase II trial, Imfinzi (durvalumab) plus Lynparza (olaparib) resulted in a decrease in PSA greater than or equal to 50% in 53% (9/17) of patients with metastatic castrate-resistant prostate cancer, with radiographic response in 4 of those 9, a median radiographic progression-free survival (PFS) of 16.1 mo., and a 12-mo. PFS probability of 83.3% in patients with mutations in DNA damage response (DDR) genes, compared to 36.4% in patients without DDR gene mutations (PMID: 30514390; NCT02484404). 30514390
Unknown unknown female reproductive organ cancer not applicable PARP Inhibitor (Pan) Durvalumab + Olaparib Phase I Actionable In a Phase I trial, the combination therapy of Imfinzi (durvalumab) and Lynparza (olaparib) resulted in an overall response rate of 17% (2/12) and disease control rate of 83% (10/12) in patients with female reproductive organ cancer (PMID: 28471727). 28471727
Unknown unknown astrocytoma not applicable PARP Inhibitor (Pan) Olaparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) resulted in decreased cell viability of some pediatric high grade astrocytoma cell lines in culture (PMID: 26351319). 26351319
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) Olaparib FDA approved Actionable In a Phase II trial that supported FDA approval, Lynparza (olaparib) maintenance therapy resulted in significantly improved progression-free survival compared to placebo (8.4 vs 4.8 mo, HR=0.35, p<0.001) in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneum cancer (PMID: 22452356; NCT00753545). 22452356 detail...
Unknown unknown prostate cancer not applicable PARP Inhibitor (Pan) Olaparib Phase II Actionable In a Phase II clinical trial, 86.7% (13/15) of metastatic castration-resistant prostate cancer patients with mutations in DNA repair genes demonstrated response to Lynparza (olaparib) treatment (Cancer Res August 1, 2015 75:CT322). detail...
Unknown unknown brain stem glioma not applicable PARP Inhibitor (Pan) Olaparib Preclinical - Cell culture Actionable In a preclinical study, Lynparza (olaparib) resulted in decreased cell viability of some diffuse intrinsic pontine glioma cell lines in culture (PMID: 26351319). 26351319
Unknown unknown colorectal cancer no benefit PARP Inhibitor (Pan) Olaparib Phase II Actionable In a Phase II clinical trial, treatment with Lynparza (olaparib) did not result in clinical activity in colorectal cancer patients that had progressed on prior standard therapy, including both microsatellite-stable patients and those that demonstrated high microsatellite instability (PMID: 26786262). 26786262
Unknown unknown head and neck cancer not applicable PARP Inhibitor (Pan) Olaparib Preclinical - Pdx Actionable In a preclinical study, a patient-dervived xenograft (PDX) model of head and neck cancer harboring mutant TP53 and wild-type ATM did not demonstrate sensitivity to Lynparza (olaparib) treatment (PMID: 31699977). 31699977
Unknown unknown stomach cancer not applicable PARP Inhibitor (Pan) Olaparib + Paclitaxel Phase III Actionable In a Phase III trial (GOLD), addition of Lynparza (olaparib) to Taxol (paclitaxel) did not significantly improve overall survival (8.8 vs 6.9 months, HR=0.79, p=0.026) compared to Taxol (paclitaxel) alone in Asian patients with advanced gastric cancer (PMID: 29103871; NCT01924533). 29103871
Unknown unknown stomach cancer not applicable PARP Inhibitor (Pan) Olaparib + Paclitaxel Phase II Actionable In a Phase II trial, addition of Lynparza (olaparib) to Taxol (paclitaxel) did not significantly improve progression free survival (3.91 vs 3.55 months) compared to Taxol alone, but did significantly prolong overall survival (13.1 vs 8.3 months) in patients with metastatic gastric cancer (PMID: 26282658; NCT01063517). 26282658
Unknown unknown glioblastoma multiforme not applicable PARP Inhibitor (Pan) Olaparib + Radiotherapy Preclinical - Cell culture Actionable In a preclinical study, treatment with Lynparza (olaparib) enhanced the sensitivity of glioblastoma cell lines to radiation therapy in culture, demonstrating greater decreased cell survival when compared to cells not treated with Lynparza (olaparib) (PMID: 32347934). 32347934
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) Olaparib + SN-38 Preclinical - Cell culture Actionable In a preclinical study, Ewing sarcoma cells treated with SN-38 combined with Lynparza (olaparib) resulted in synergism, demonstrating reduced cell viability in culture (PMID: 26438158). 26438158
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) Olaparib + SN-38 + Temozolomide Preclinical - Cell culture Actionable In a preclinical study, Ewing sarcoma cells treated with the combination of Temodar (temozolomide), SN-38, and Lynparza (olaparib) had a much greater effect on decreasing cell viability and inducing apoptosis when compared to each treatment administered as a single agent or as dual agents in culture (PMID: 26438158). 26438158
Unknown unknown colorectal cancer not applicable PARP Inhibitor (Pan) Olaparib + Temozolomide Preclinical - Cell line xenograft Actionable In a preclinical study, the addition of Lynparza (olaparib) to Temodar (temozolomide) resulted in greater antitumor activity than Temodar (temozolomide) alone in colorectal cancer cell line xenograft models, demonstrating decreased tumor volume (PMID: 27550455). 27550455
Unknown unknown lung small cell carcinoma not applicable PARP Inhibitor (Pan) Olaparib + Temozolomide Phase Ib/II Actionable In a Phase I/II trial, combination of Lynparza (olaparib) and Temodar (temozolomide) resulted in an objective response rate of 41.7% (20/48) in patients with relapsed small cell lung cancer, with a median progression-free survival of 4.2 months and a median overall survival of 8.5 months, similar response was recapitulated in a coclinical trial with 32 patient-derived xenograft models (PMID: 31416802; NCT02446704). 31416802
Unknown unknown Ewing sarcoma not applicable PARP Inhibitor (Pan) Olaparib + Temozolomide Preclinical - Cell culture Actionable In a preclinical study, Ewing sarcoma cells treated with Temodar (temozolomide) combined with Lynparza (olaparib) resulted in very strong synergism, inducing apoptosis and reducing cell viability in culture (PMID: 26438158). 26438158
Unknown unknown glioblastoma multiforme not applicable PARP Inhibitor (Pan) Olaparib + Temozolomide Phase II Actionable In a Phase II trial (OPARATIC), 36% (14/39) of evaluable patients with glioblastoma were progression-free at 6 months when treated with the combination therapy of Lynparza (olaparib) and Temodar (temozolomide) (PMID: 32347934; NCT0139057). 32347934
Unknown unknown sarcoma not applicable PARP Inhibitor (Pan) Olaparib + Trabectedin Phase Ib/II Actionable In a Phase Ib trial, 14% (7/50) of patients with either bone or soft tissue sarcoma demonstrated a partial response according to RECIST criteria when treated with the combination therapy of Lynparza (olaparib) and Yondelis (trabectedin) (PMID: 30217671). 30217671
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) Carboplatin + E7449 Preclinical - Cell line xenograft Actionable In a preclinical study, the combination of E7449 and Paraplatin (carboplatin) synergized to inhibit tumor growth in a human breast cancer cell line xenograft model (PMID: 26513298). 26513298
Unknown unknown Advanced Solid Tumor not applicable PARP Inhibitor (Pan) E7449 Phase I Actionable In a Phase I trial, E7449 treatment demonstrated safety and resulted in an overall response rate of 4.9% (2/41, partial responses) and stable disease in 31.7% (13/41) of patients with advanced solid tumors, including stable disease lasting greater than 23 weeks in 8 patients (PMID: 32523090; NCT01618136). 32523090
Unknown unknown pancreatic cancer not applicable PARP Inhibitor (Pan) E7449 Phase I Actionable In a Phase I trial, E7449 treatment inhibited Parp activity in peripheral blood mononuclear cells and resulted in stable disease for more than 24 weeks in 7 patients with pancreatic cancer (J Clin Oncol 36, 2018 (suppl; abstr 2505); abstr e19531; NCT01618136). detail...
Unknown unknown ovarian cancer not applicable PARP Inhibitor (Pan) E7449 Phase I Actionable In a Phase I trial, E7449 treatment inhibited Parp activity in peripheral blood mononuclear cells and resulted in partial response in 40% (2/5) of the patients with ovarian cancer (J Clin Oncol 36, 2018 (suppl; abstr 2505); abstr e19531; NCT01618136). detail...
Unknown unknown melanoma not applicable PARP Inhibitor (Pan) E7449 + Temozolomide Preclinical Actionable In a preclinical study, the combination of E7449 and Temodar (temozolomide) inhibited tumor growth in mouse melanoma models, with increased efficacy compared to either agent alone (PMID: 26513298). 26513298
Unknown unknown breast cancer not applicable PARP Inhibitor (Pan) AsiDNA + AZD2461 Preclinical - Cell culture Actionable In a preclinical study, AsiDNA and AZD2461 combination treatment resulted in increased cell death and inhibition of proliferation in breast cancer cell lines compared to AZD2461 alone in culture (PMID: 27559053). 27559053
Unknown unknown colorectal cancer not applicable PARP Inhibitor (Pan) AZD2461 + Temozolomide Preclinical - Cell line xenograft Actionable In a preclinical study, the addition of AZD2461 to Temodar (temozolomide) resulted in greater antitumor activity than Temodar (temozolomide) alone in colorectal cancer cell line xenograft models, demonstrating decreased tumor volume (PMID: 27550455). 27550455
Clinical Trial Phase Therapies Title Recruitment Status