Molecular Profile Detail

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Profile Name MLH1 M524I PDGFRA W559_R560del
Gene Variant Detail

MLH1 M524I (unknown)

PDGFRA W559_R560del (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MLH1 M524I PDGFRA W559_R560del gastrointestinal stromal tumor predicted - sensitive Imatinib Case Reports/Case Series Actionable In a clinical case study, Gleevec (imatinib) treatment resulted in disease-free survival for over 10 months in a patient with epithelioid variant of gastrointestinal stromal tumor harboring PDGFRA W559_R560del and MLH1 M524I (PMID: 31273885). 31273885
Clinical Trial Phase Therapies Title Recruitment Status