Molecular Profile Detail


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Profile Name SRSF2 P95L
Gene Variant Detail

SRSF2 P95L (loss of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
SRSF2 P95L acute myeloid leukemia predicted - sensitive E7107 Preclinical - Pdx Actionable In a preclinical study, E7107 treatment induced apoptosis and resulted in reduced tumor burden in a patient-derived xenograft (PDX) model of acute myeloid leukemia harboring SRSF2 P95L (PMID: 27135740). 27135740
SRSF2 P95L hematologic cancer sensitive GSK3203591 + MS023 Preclinical - Cell culture Actionable In a preclinical study, hematopoietic progenitor cells differentiated from iPSCs harboring SRSF2 P95L demonstrated increased sensitivity to GSK3203591 and MS023 combination treatment compare to SRSF2 wild-type cells in culture (PMID: 31408619). 31408619
Clinical Trial Phase Therapies Title Recruitment Status