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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KIT V654A KIT D816V||Advanced Solid Tumor||resistant||Midostaurin||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells co-expressing KIT D816V and KIT V654A demonstrated resistance to treatment with Rydapt (midostaurin) in culture compared to cells expressing KIT D816V alone (PMID: 31270078).||31270078|
|KIT V654A KIT D816V||Advanced Solid Tumor||predicted - sensitive||Avapritinib||Preclinical - Cell culture||Actionable||In a preclinical study, transformed cells co-expressing KIT D816V and KIT V654A demonstrated some sensitivity to treatment with Ayvakit (avapritinib) in culture (PMID: 31270078).||31270078|