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|Profile Name||KIT Y568_L576delinsCV KIT D816E KIT D820Y|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|KIT Y568_L576delinsCV KIT D816E KIT D820Y||gastrointestinal stromal tumor||predicted - sensitive||Ripretinib||Case Reports/Case Series||Actionable||In a Phase I trial, treatment with Qinlock (ripretinib) decreased circulating tumor DNA, resulted in stable disease lasting over 21 months in a patient with gastrointestinal stromal tumor harboring a primary KIT Y568_L576delinsCV mutation and two acquired resistance mutations, KIT D816E and KIT D820Y (PMID: 31085175; NCT02571036).||31085175|