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Profile Name | ATRX fusion |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
ATRX fusion | neuroblastoma | predicted - sensitive | UNC1999 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with UNC1999 resulted in reduced proliferation and increased apoptosis of neuroblastoma cell lines harboring in-frame ATRX fusions in culture, and decreased tumor growth in a neuroblastoma cell line xenograft model harboring an ATRX fusion (PMID: 31631027). | 31631027 | |
ATRX fusion | neuroblastoma | predicted - sensitive | Tazemetostat | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with Tazemetostat (EPZ-6438) resulted in reduced proliferation and increased apoptosis of neuroblastoma cell lines harboring in-frame ATRX fusions in culture (PMID: 31631027). | 31631027 | |
ATRX fusion | neuroblastoma | predicted - sensitive | GSK126 | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with GSK126 resulted in reduced proliferation and increased apoptosis of neuroblastoma cell lines harboring in-frame ATRX fusions in culture (PMID: 31631027). | 31631027 |