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|Profile Name||EZH2 A682G|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|EZH2 A682G||lymphoma||sensitive||Tazemetostat||Preclinical - Cell line xenograft||Actionable||In a preclinical study, treatment with Tazemetostat (EPZ-6438) inhibited proliferation and induced apoptosis in lymphoma cell lines harboring EZH2 A682G in culture, and complete tumor regression in cell line xenograft models (PMID: 24563539).||24563539|
|EZH2 A682G||follicular lymphoma||sensitive||Tazemetostat||FDA approved - On Companion Diagnostic||Actionable||In a Phase II trial that supported FDA approval, Tazverik (tazemetostat) treatment was well-tolerated, resulted in a median progression-free survival of 11.1 months, objective response in 77% (33/43), and stable disease in 23% (10/43) of patients with relapsed or refractory follicular lymphoma, who had two or more prior therapies and harbored EZH2 mutations as detected by an approved test, including EZH2 A682G (Blood (2019) 134 (Supplement_1):123; NCT01897571).||detail... detail... detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|