Molecular Profile Detail


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Profile Name EZH2 A682G
Gene Variant Detail

EZH2 A682G (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
EZH2 A682G lymphoma sensitive Tazemetostat Preclinical - Cell line xenograft Actionable In a preclinical study, treatment with Tazemetostat (EPZ-6438) inhibited proliferation and induced apoptosis in lymphoma cell lines harboring EZH2 A682G in culture, and complete tumor regression in cell line xenograft models (PMID: 24563539). 24563539
EZH2 A682G follicular lymphoma sensitive Tazemetostat FDA approved - On Companion Diagnostic Actionable In a Phase II trial that supported FDA approval, Tazverik (tazemetostat) treatment was well-tolerated, resulted in a median progression-free survival of 11.1 months, objective response in 77% (33/43), and stable disease in 23% (10/43) of patients with relapsed or refractory follicular lymphoma, who had two or more prior therapies and harbored EZH2 mutations as detected by an approved test, including EZH2 A682G (Blood (2019) 134 (Supplement_1):123; NCT01897571). detail... detail... detail...
Clinical Trial Phase Therapies Title Recruitment Status