Molecular Profile Detail


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Profile Name KMT2A - AFDN
Gene Variant Detail

KMT2A - AFDN (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A - AFDN acute myeloid leukemia predicted - sensitive CYC065 Preclinical - Cell culture Actionable In a preclinical study, an acute myeloid leukemia cell line harboring KMT2A-AFDN was sensitive to treatment with CYC065 (Fadraciclib) in culture, demonstrating decreased cell viability (PMID: 32645016). 32645016
KMT2A - AFDN acute myeloid leukemia predicted - sensitive DSP-5336 Preclinical - Patient cell culture Actionable In a preclinical study, DSP-5336 treatment inhibited blast colony formation in patient-derived acute myeloid leukemia cells harboring KMT2A-AFDN (reported as MLL-AF6) in culture (Blood (2021) 138 (Supplement 1): 3339). detail...