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|Profile Name||FGFR2 Y376C|
|Gene Variant Detail|
|Relevant Treatment Approaches||FGFR Inhibitor (Pan) FGFR2 Inhibitor|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 Y376C||intrahepatic cholangiocarcinoma||predicted - sensitive||FGFR2 Inhibitor||AZD4547||Case Reports/Case Series||Actionable||In a Phase II (MATCH) trial, AZD4547 treatment resulted in an overall response rate of 10.5% (2/19) in patients with advanced solid tumors harboring FGFR2 or 3 activating single nucleotide variants and a 6-month progression-free survival rate of 6%, including a partial response with 69% reduction in target lesion size and progression-free survival of 9.8 months in a patient with intrahepatic cholangiocarcinoma harboring FGFR2 Y376C (PMID: 32463741; NCT02465060).||32463741|