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Profile Name | PALB2 I944N |
Gene Variant Detail | |
Relevant Treatment Approaches | PARP Inhibitor (Pan) |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
PALB2 I944N | Advanced Solid Tumor | sensitive | PARP Inhibitor (Pan) | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing PALB2 I944N were sensitive to treatment with Lynparza (olaparib) in culture, demonstrating decreased cell survival (PMID: 31636395). | 31636395 |