Molecular Profile Detail


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Profile Name FGFR2 - TTC28
Gene Variant Detail

FGFR2 - TTC28 (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 - TTC28 cholangiocarcinoma sensitive Infigratinib Preclinical - Pdx Actionable In a preclinical study, Truseltiq (infigratinib) treatment inhibited tumor growth in a patient-derived xenograft (PDX) model of cholangiocarcinoma harboring FGFR2-TTC28 fusion (Cancer Res 2019;79(13 Suppl):Abstract nr 2206). detail...
FGFR2 - TTC28 intrahepatic cholangiocarcinoma predicted - sensitive Futibatinib Case Reports/Case Series Actionable In a Phase I trial, Futibatinib (TAS-120) treatment at a dose of 16mg led to a partial response in 42.1% (8/19) of patients with intrahepatic cholangiocarcinoma harboring FGF or FGFR alterations, including a partial response with a progression-free survival of 24.1 months and a duration of response of 12.7 months in a patient harboring FGFR2-TTC28 (PMID: 34551969; NCT02052778). 34551969
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries