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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|NOTCH1 L1600Q NOTCH1 S2467fs||adenoid cystic carcinoma||predicted - sensitive||Brontictuzumab||Case Reports/Case Series||Actionable||In a clinical case study, a patient with metastatic adenoid cystic carcinoma harboring co-occurring NOTCH1 L1600Q and S2467fs achieved a partial response after 2 doses of Brontictuzumab (OMP-52M51), however, his disease progressed shortly after treatment discontinuation (PMID: 27870570).||27870570|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|