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Profile Name | FBXW7 W606* NOTCH1 L1600Q NOTCH1 V1721G NOTCH1 S2467fs |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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FBXW7 W606* NOTCH1 L1600Q NOTCH1 V1721G NOTCH1 S2467fs | adenoid cystic carcinoma | no benefit | Sunitinib | Case Reports/Case Series | Actionable | In a clinical case study, Sutent (sunitinib) treatment resulted in rapid disease progression in a patient with metastatic adenoid cystic carcinoma harboring co-occurring NOTCH1 L1600Q and S2467fs, and acquired FBXW7 W606* and NOTCH1 V1721G (PMID: 27870570). | 27870570 | |
FBXW7 W606* NOTCH1 L1600Q NOTCH1 V1721G NOTCH1 S2467fs | adenoid cystic carcinoma | predicted - resistant | Brontictuzumab | Case Reports/Case Series | Actionable | In a clinical case study, FBXW7 W606* and NOTCH1 V1721G were identified at disease progression in a patient with metastatic adenoid cystic carcinoma harboring co-occurring NOTCH1 L1600Q and S2467fs who was treated with Brontictuzumab (OMP-52M51) (PMID: 27870570). | 27870570 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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