Molecular Profile Detail


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Profile Name BCORL1 Q1076H BRAF V47_D380del BRAF V600E
Gene Variant Detail

BCORL1 Q1076H (unknown)

BRAF V47_D380del (gain of function - predicted)

BRAF V600E (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BCORL1 Q1076H BRAF V47_D380del BRAF V600E melanoma resistant Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, a melanoma cell line harboring BRAF V600E was found to have BRAF V47_D380del and BCORL1 Q1076H mutations after acquiring resistance to Zelboraf (vemurafenib), and expression of BRAF V47_D380del and BCORL1 Q1076H in a BRAF V600E-positive melanoma cell line resulted in decreased sensitivity to Zelboraf (vemurafenib) in culture (PMID: 29605720). 29605720
Clinical Trial Phase Therapies Title Recruitment Status