Molecular Profile Detail


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Profile Name RUNX1 rearrange SF3B1 K700E
Gene Variant Detail

RUNX1 rearrange (unknown)

SF3B1 K700E (loss of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
RUNX1 rearrange SF3B1 K700E acute myeloid leukemia sensitive EPZ015666 + MS023 Preclinical - Pdx Actionable In a preclinical study, MS023 and EPZ015666 (GSK3235025) combination treatment reduced tumor burden in a patient-derived xenograft (PDX) model of acute myeloid leukemia cells harboring RUNX1 rearrangement and SF3B1 K700E (PMID: 31408619). 31408619
Clinical Trial Phase Therapies Title Recruitment Status