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|Profile Name||FGFR2 H167_N173del FGFR2 L617F|
|Gene Variant Detail||
FGFR2 H167_N173del (gain of function)
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR2 H167_N173del FGFR2 L617F||intrahepatic cholangiocarcinoma||predicted - resistant||Debio 1347||Case Reports/Case Series||Actionable||In a clinical study, a patient with intrahepatic cholangiocarcinoma harboring FGFR2 H167_N173del developed resistance to Debio 1347 treatment after initial response, FGFR2 L617F was identified as an acquired mutation at disease progression (J Clin Oncol 38, 2020 (suppl 4; abstr 567)).||detail...|