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|Profile Name||ROS1 - GOPC|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ROS1 - GOPC||rectosigmoid cancer||predicted - sensitive||Entrectinib||Case Reports/Case Series||Actionable||In a clinical case study, Rozlytrek (entrectinib) treatment resulted in a 16% reduction of tumor burden in a patient with advanced rectosigmoid adenocarcinoma harboring ROS1-GOPC who enrolled in a Phase II trial, and the patient remained on treatment after 9 months (PMID: 33414136; NCT02568267).||33414136|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|