Molecular Profile Detail


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Profile Name MAP2K1 K57_G61del
Gene Variant Detail

MAP2K1 K57_G61del (gain of function - predicted)

Relevant Treatment Approaches MEK inhibitor (Pan) MEK1 Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MAP2K1 K57_G61del lymphatic system cancer predicted - sensitive MEK inhibitor (Pan) MEK1 Inhibitor Trametinib Case Reports/Case Series Actionable In a clinical case study, a pediatric patient with Langerhans cell histiocytosis harboring MAP2K1 K57_G61del treated with Mekinist (trametinib) achieved a rapid complete response and had no active disease over 22 months of treatment (PMID: 32991018). 32991018
MAP2K1 K57_G61del Advanced Solid Tumor sensitive MEK inhibitor (Pan) MEK1 Inhibitor Trametinib Preclinical - Cell culture Actionable In a preclinical study, Mekinist (trametinib) inhibited viability of a transformed cell line expressing MAP2K1 K57_G61del in culture (PMID: 36442478). 36442478