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Profile Name | TP53 Q331* |
Gene Variant Detail | |
Relevant Treatment Approaches | p53 Gene Therapy |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK TP53 Q331* | lung non-small cell carcinoma | resistant | Alectinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cells harboring EML4-ALK and TP53 Q331* were resistant to treatment with Alecensa (alectinib) in culture (PMID: 33310890). | 33310890 |
EML4 - ALK TP53 Q331* | lung non-small cell carcinoma | resistant | Crizotinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cells harboring EML4-ALK and TP53 Q331* were resistant to treatment with Xalkori (crizotinib) in culture (PMID: 33310890). | 33310890 |
EML4 - ALK TP53 Q331* | lung non-small cell carcinoma | sensitive | Alectinib + Ixazomib | Preclinical - Cell culture | Actionable | In a preclinical study, the combination therapy of Alecensa (alectinib) and Ninlaro (ixazomib) inhibited the proliferation of non-small cell lung cancer cells harboring EML4-ALK and TP53 Q331* in culture (PMID: 33310890). | 33310890 |