Molecular Profile Detail


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Profile Name CTNNB1 S33Y PIK3CA mut
Gene Variant Detail

CTNNB1 S33Y (gain of function)

PIK3CA mutant (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 S33Y PIK3CA mut colon cancer resistant NVP-TNKS656 + Trametinib Preclinical - Cell culture Actionable In a preclinical study, PIK3CA mutant colon cancer cells expressing CTNNB1 S33Y demonstrated suppression of cell death following Mekinist (trametinib) and NVP-TNKS656 combination treatment in culture (PMID: 30944457). 30944457
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries