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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF loss NRAS Q61K||melanoma||decreased response||LXH 254||Preclinical - Cell culture||Actionable||In a preclinical study, CRISPR-Cas9 mediated knockout of BRAF in a melanoma cell line harboring NRAS Q61K led to decreased sensitivity to LXH254 treatment compared to parental cells harboring BRAF D287H and NRAS Q61K in culture (PMID: 33355204).||33355204|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|