Molecular Profile Detail


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Profile Name ARID1A Y788* ARID1A M1154fs
Gene Variant Detail

ARID1A M1154fs (loss of function - predicted)

ARID1A Y788* (loss of function - predicted)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ARID1A Y788* ARID1A M1154fs ovarian clear cell carcinoma predicted - sensitive Bevacizumab + Pembrolizumab Case Reports/Case Series Actionable In a clinical case study, a patient with ovarian clear cell carcinoma harboring both ARID1A Y788* and M1154fs was sensitive to the combination therapy of Keytruda (pembrolizumab) and Avastin (bevacizumab), demonstrating a decrease in serum marker, tumor regression after 3 cycles, and complete remission after 9 cycles of treatment (PMID: 33292376). 33292376