Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Profile Name||FGFR3 - PHGDH|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR3 - PHGDH||childhood oligodendroglioma||predicted - sensitive||Ponatinib||Case Reports/Case Series||Actionable||In a clinical case study, a pediatric thalamic oligodendroglioma patient who achieved a partial response when treated with radiation therapy, was found to harbor an FGFR3-PHGDH fusion, and subsequent Iclusig (ponatinib) treatment led to a tumor reduction of 15% (compared to post-radiation scans), and an ongoing partial response lasting seven moths post-treatment initiation (PMID: 29872711).||29872711|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|