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|Profile Name||BRAF class 1|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF class 1||melanoma||predicted - sensitive||Exarafenib||Preclinical - Cell line xenograft||Actionable||In a preclinical study, Exarafenib (KIN-2787) treatment led to inhibition of tumor growth in a melanoma cell line xenograft model harboring a BRAF class 1 mutation (J of Clin Oncol 39, no. 15_suppl (May 20, 2021) 3116-3116).||detail...|
|BRAF class 1||Advanced Solid Tumor||predicted - sensitive||BDTX-4933||Preclinical - Cell culture||Actionable||In a preclinical study, BDTX-4933 inhibited proliferation of cells expressing a BRAF class 1 mutation in culture (Eur J Cancer (2022), Vol 174, Supplement 1: S86).||detail...|
|BRAF class 1||Advanced Solid Tumor||predicted - sensitive||Exarafenib||Case Reports/Case Series||Actionable||In a Phase I trial, Exarafenib (KIN-2787) was tolerated and resulted in a partial response in 17.6% (6/34) and stable disease in 23.5% (8/34) of patients with BRAF-driven advanced solid tumors or NRAS-driven melanoma, including 3 partial responses in patients harboring BRAF class 1 mutations (Cancer Res (2023) 83 (8_Supplement): CT032; NCT04913285).||detail...|
|BRAF class 1||Advanced Solid Tumor||predicted - sensitive||DCC-3084||Preclinical - Cell culture||Actionable||In a preclinical study, DCC-3084 inhibited downstream signaling and proliferation in cells expressing a BRAF class 1 mutation in culture (Cancer Res (2023) 83 (7_Supplement): 4045).||detail...|