Molecular Profile Detail


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Profile Name BRAF class 1
Gene Variant Detail

BRAF class 1 (gain of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF class 1 melanoma predicted - sensitive KIN-2787 Preclinical - Cell line xenograft Actionable In a preclinical study, KIN-2787 treatment led to inhibition of tumor growth in a melanoma cell line xenograft model harboring a BRAF class 1 mutation (J of Clin Oncol 39, no. 15_suppl (May 20, 2021) 3116-3116). detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04913285 Phase I Binimetinib + KIN-2787 KIN-2787 A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors Recruiting USA | FRA | ESP 2
NCT05512208 Phase II Defactinib + RO5126766 A Phase 2 Study of VS-6766 Plus Defactinib Not yet recruiting USA 0