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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF V600E CDKN2A loss CHEK2 dec exp RB1 pos||melanoma||predicted - resistant||Palbociclib + Vemurafenib||Preclinical - Cell culture||Actionable||In a preclinical study, Ibrance (palbociclib) and Zelboraf (vemurafenib) combination therapy in a melanoma cell line harboring BRAF V600E, CDKN2A loss, RB1 expression, and decreased expression of CHEK2 via siRNA resulted in increased cell proliferation and p-ERK levels compared to treated cells without decreased expression of CHEK2 in culture (PMID: 33947696).||33947696|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|