Molecular Profile Detail


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Profile Name BRAF V600E CDKN2A loss CHEK2 dec exp RB1 pos
Gene Variant Detail

BRAF V600E (gain of function)

CDKN2A loss (loss of function)

CHEK2 dec exp (no effect)

RB1 positive (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E CDKN2A loss CHEK2 dec exp RB1 pos melanoma predicted - resistant Palbociclib + Vemurafenib Preclinical - Cell culture Actionable In a preclinical study, Ibrance (palbociclib) and Zelboraf (vemurafenib) combination therapy in a melanoma cell line harboring BRAF V600E, CDKN2A loss, RB1 expression, and decreased expression of CHEK2 via siRNA resulted in increased cell proliferation and p-ERK levels compared to treated cells without decreased expression of CHEK2 in culture (PMID: 33947696). 33947696
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries