Molecular Profile Detail

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Profile Name KMT2A - AFF4
Gene Variant Detail

KMT2A - AFF4 (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KMT2A - AFF4 leukemia no benefit Decitabine + Tretinoin Preclinical - Cell culture Actionable In a preclinical study, combination treatment of Tretinoin and Dacogen (decitabine) in murine leukemic cells expressing a KMT2A-AFF4 fusion did not result in upregulation of Mac-1 and C/EBPalpha and resulted in similar growth compared to untreated cells in culture (PMID: 23063977). 23063977
KMT2A - AFF4 leukemia predicted - sensitive Tranylcypromine + Tretinoin Preclinical - Cell culture Actionable In a preclinical study, the addition of Parnate (tranylcypromine) resulted in increased sensitivity to Tretinoin treatment in a murine leukemic cell line harboring a KMT2A-AFF4 fusion (also known as MLL-AF5q31), with inhibition of cell growth and CD11b expression in culture (Blood (2012) 120 (21): 1345.). detail...
KMT2A - AFF4 leukemia no benefit Tretinoin Preclinical - Cell culture Actionable In a preclinical study, treatment with Tretinoin in murine leukemic cells expressing a KMT2A-AFF4 fusion did not result in upregulation of Mac-1 and C/EBPalpha and resulted in similar growth compared to untreated cells in culture (PMID: 23063977). 23063977
KMT2A - AFF4 leukemia predicted - sensitive Abemaciclib Preclinical - Cell culture Actionable In a preclinical study, treatment with Verzenio (abemaciclib) induced apoptosis, reduced expression of Brd4 and Brd4-regulated proteins, including c-Myc, Cdk6, and Bcl-2, and resulted in an anti-tumor effect by inducing cell cycle arrest in leukemia cells harboring a KMT2A-AFF4 fusion that had developed resistance to Birabresib (OTX015) in culture (Cancer Res 2020;80(16 Suppl):Abstract nr 643.) detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries