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|Profile Name||BRAF V600E CDKN2A loss NRAS Q61K|
|Gene Variant Detail||
CDKN2A loss (loss of function)
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF V600E CDKN2A loss NRAS Q61K||melanoma||predicted - resistant||Cobimetinib + Vemurafenib||Case Reports/Case Series||Actionable||In a clinical case study, a melanoma patient harboring BRAF V600E and NRAS Q61K experienced progressive disease after a response to combination therapy with Zelboraf (vemurafenib) and Cotellic (cobimetinib), land was found to have acquired loss of CDKN2A (PMID: 34376578).||34376578|