Molecular Profile Detail

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Profile Name ROS1 fusion ROS1 S1986F ROS1 L2000V
Gene Variant Detail

ROS1 fusion (unknown)

ROS1 L2000V (unknown)

ROS1 S1986F (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 fusion ROS1 S1986F ROS1 L2000V lung non-small cell carcinoma predicted - resistant Lorlatinib Case Reports/Case Series Actionable In a clinical case study, a patient with non-small cell lung cancer harboring a ROS1 fusion who had progressed on Xalkori (crizotinib) was subsequently treated with Lorbrena (lorlatinib) but progression ensued and post treatment biopsy revealed acquisition of ROS1 S1986F and ROS1 L2000V (PMID: 33685866). 33685866
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries