Molecular Profile Detail


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Profile Name CHEK2 inact mut FANCA inact mut PTEN inact mut
Gene Variant Detail

CHEK2 inact mut (loss of function)

FANCA inact mut (loss of function)

PTEN inact mut (loss of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
CHEK2 inact mut FANCA inact mut PTEN inact mut Her2-receptor negative breast cancer predicted - sensitive Talazoparib Case Reports/Case Series Actionable In a Phase II trial, Talzenna (talazoparib) treatment was well tolerated, and among 12 evaluable ERBB2 (HER2)-negative breast cancer patients with a homologous repair pathway mutation resulted in response in 25% (3/12) of patients, including a patient with germline mutations in CHEK2 and FANCA, and a somatic PTEN mutation (J Clin Oncol 37, no. 15_suppl (May 20, 2019) 3006). detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries