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|Profile Name||ALK R1275L|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ALK R1275L||neuroblastoma||predicted - sensitive||Crizotinib||Case Reports/Case Series||Actionable||In a Phase I/II trial, Xalkori (crizotinib) treatment was well-tolerated and resulted in stable disease in a pediatric patient with neuroblastoma harboring ALK R1275L who stayed on treatment for 4 cycles (PMID: 23598171; NCT00939770).||23598171|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|