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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|PALB2 Y551* PALB2 S859*||Her2-receptor negative breast cancer||predicted - sensitive||Olaparib||Case Reports/Case Series||Actionable||In a clinical case study, a patient with metastatic hormone receptor (ESR1/PGR)-positive, ERBB2 (HER2)-negative breast cancer harboring PALB2 Y551* and S859* who progressed on prior therapies achieved a partial response to Lynparza (olaparib) treatment after 3 months and a 70% decrease in tumor burden at 6 months (PMID: 32194151).||32194151|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|