Molecular Profile Detail


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Profile Name PALB2 Y551* PALB2 S859*
Gene Variant Detail

PALB2 S859* (loss of function - predicted)

PALB2 Y551* (loss of function)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PALB2 Y551* PALB2 S859* Her2-receptor negative breast cancer predicted - sensitive Olaparib Case Reports/Case Series Actionable In a clinical case study, a patient with metastatic hormone receptor (ESR1/PGR)-positive, ERBB2 (HER2)-negative breast cancer harboring PALB2 Y551* and S859* who progressed on prior therapies achieved a partial response to Lynparza (olaparib) treatment after 3 months and a 70% decrease in tumor burden at 6 months (PMID: 32194151). 32194151
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries