Molecular Profile Detail

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Profile Name AXL over exp BRAF V600E
Gene Variant Detail

AXL over exp (no effect)

BRAF V600E (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
AXL over exp BRAF V600E melanoma sensitive Bemcentinib + Vemurafenib Preclinical - Cell line xenograft Actionable In a preclinical study, Bemcentinib (BGB-324) and Zelboraf (vemurafenib) combination treatment synergistically inhibited viability of melanoma cell lines harboring BRAF V600E and overexpressing Axl in culture, and resulted in improved tumor growth inhibition and tumor regression over either agent alone in a cell line xenograft model (PMID: 35332208). 35332208
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries