Molecular Profile Detail


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Profile Name BRAF G469A CBL C404Y FLT3 exon 14 ins FLT3 D835X
Gene Variant Detail

BRAF G469A (gain of function)

CBL C404Y (unknown)

FLT3 D835X (unknown)

FLT3 exon 14 ins (gain of function - predicted)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G469A CBL C404Y FLT3 exon 14 ins FLT3 D835X acute myeloid leukemia predicted - resistant Gilteritinib Case Reports/Case Series Actionable In a clinical study, a patient with acute myeloid leukemia harboring FLT3-ITD and a D835 mutation progressed on Xospata (gilteritinib) treatment and was found to have acquired CBL C404Y and BRAF G469A (PMID: 31088841). 31088841