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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ALK G1202R ALK D1276_R1279delinsE||neuroblastoma||predicted - resistant||Crizotinib||Case Reports/Case Series||Actionable||In a clinical case study, a neuroblastoma patient harboring ALK D1276_R1279delinsE developed progressive disease on treatment with Xalkori (crizotinib) and was found to have acquired ALK G1202R via circulating tumor DNA (PMID: 37147298).||37147298|
|ALK G1202R ALK D1276_R1279delinsE||neuroblastoma||predicted - sensitive||Lorlatinib||Case Reports/Case Series||Actionable||In a Phase I trial, Lorbrena (lorlatinib) treatment resulted in a complete metabolic response and a partial anatomic response in a neuroblastoma patient harboring ALK D1276_R1279delinsE and G1202R, who remained on the treatment for over 27 cycles (PMID: 37147298; NCT03107988).||37147298|