Molecular Profile Detail

Profile Name PTEN mut RB1 mut SMAD4 mut TP53 mut
Gene Variant Detail

PTEN mutant (unknown)

RB1 mutant (unknown)

SMAD4 mutant (unknown)

TP53 mutant (unknown)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN mut RB1 mut SMAD4 mut TP53 mut skin cancer sensitive Sapanisertib Preclinical Actionable In a preclinical study, a skin cancer cell line harboring mutations in PTEN, RB1, SMAD4 and TP53 demonstrated sensitivity to Sapanisertib (MLN0128) in culture (PMID: 25261369). 25261369
Clinical Trial Phase Therapies Title Recruitment Status