Molecular Profile Detail

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 P262H Advanced Solid Tumor sensitive Duligotuzumab Preclinical Actionable In a preclinical study, MEHD7945A inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive PD-0325901 + Pictilisib Preclinical Actionable In a preclinical study, the combination of GDC-0941 and PD-0325901 (PI3K and MEK inhibitors, respectively) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive HER2 Inhibitor Lapatinib Preclinical Actionable In a preclinical study, Tykerb (lapatinib) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive Trastuzumab Trastuzumab Preclinical Actionable In a preclinical study, Herceptin (trastuzumab) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor sensitive Pertuzumab Pertuzumab Preclinical Actionable In a preclinical study, Perjeta (pertuzumab) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H breast cancer sensitive Patritumab deruxtecan Preclinical - Cell culture Actionable In a preclinical study, Patritumab deruxtecan (U3-1402) treatment inhibited growth of a breast cancer cell line expressing ERBB3 (HER3) P262H in culture (PMID: 35503762). 35503762
ERBB3 P262H Advanced Solid Tumor sensitive Pictilisib Preclinical Actionable In a preclinical study, the PI3K inhibitor GDC-0941 inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) P262H (PMID: 23680147). 23680147
ERBB3 P262H Advanced Solid Tumor resistant Cetuximab Preclinical Actionable In a preclinical study, transformed cell lines expressing ERBB3 (HER3) P262H demonstrated resistance to treatment with Erbitux (cetuximab) (PMID: 23680147). 23680147
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries