Molecular Profile Detail

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Profile Name FLT3 D835A
Gene Variant Detail

FLT3 D835A (gain of function)

Relevant Treatment Approaches FLT3 Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 D835A hematologic cancer sensitive FLT3 Inhibitor Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) inhibited Flt3 autophosphorylation and viability in transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer sensitive FLT3 Inhibitor Lestaurtinib Preclinical - Cell culture Actionable In a preclinical study, Lestaurtinib (CEP-701) inhibited Flt3 autophosphorylation and viability in transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer no benefit FLT3 Inhibitor AG1295 Preclinical - Cell culture Actionable In a preclinical study, AG1295 did not inhibit viability of transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer no benefit FLT3 Inhibitor Linifanib Preclinical - Cell culture Actionable In a preclinical study, Linifanib (ABT-869) did not inhibit viability of transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer no benefit FLT3 Inhibitor Quizartinib Preclinical - Cell culture Actionable In a preclinical study, Vanflyta (quizartinib) did not inhibit viability of transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer no benefit FLT3 Inhibitor Sunitinib Preclinical - Cell culture Actionable In a preclinical study, Sutent (sunitinib) did not inhibit viability of transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer no benefit FLT3 Inhibitor Sorafenib Preclinical - Cell culture Actionable In a preclinical study, Nexavar (sorafenib) did not inhibit viability in transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer no benefit Tamatinib Preclinical - Cell culture Actionable In a preclinical study, Tamatinib (R406) did not inhibit viability of transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790
FLT3 D835A hematologic cancer sensitive FLT3 Inhibitor KW-2449 Preclinical - Cell culture Actionable In a preclinical study, KW-2449 inhibited Flt3 autophosphorylation and viability in transformed cells expressing FLT3 D835A in culture (PMID: 28077790). 28077790