Molecular Profile Detail

Profile Name PDGFRA V561D
Gene Variant Detail

PDGFRA V561D (gain of function)

Relevant Treatment Approaches PDGFR Inhibitor (Pan) PDGFR-alpha Inhibitor

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRA V561D Advanced Solid Tumor sensitive PDGFR Inhibitor (Pan) Imatinib Preclinical Actionable In a preclinical study, cells expressing PDGFRA V561D demonstrated sensitivity to Gleevec (imatinib) in cell culture (PMID: 15928335). 15928335
PDGFRA V561D Advanced Solid Tumor sensitive PDGFR-alpha Inhibitor Avapritinib Preclinical - Cell culture Actionable In a preclinical study, BLU-285 inhibited Kit phosphorylation in transformed cells overexpressing PDGFRA V561D in culture (PMID: 29093181). 29093181
Clinical Trial Phase Therapies Title Recruitment Status