Molecular Profile Detail

Profile Name SMO W281C
Gene Variant Detail

SMO W281C (no effect - predicted)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMO W281C Advanced Solid Tumor sensitive JQ1 Preclinical Actionable In a preclinical study, JQ1 inhibited proliferation of primary cerebellar granule neuron precursor cells over expressing SMO W281C on the background of PTCH1 and TP53 deletion in cell culture (PMID: 25759019). 25759019
SMO W281C Advanced Solid Tumor decreased response Sonidegib Preclinical Actionable In a preclinical study, primary cerebellar granule neuron precursor cells over expressing SMO W281C on the background of PTCH1 and TP53 deletion demonstrated reduced response to Odomzo (sonidegib) induced growth inhibition in cell culture (PMID: 25759019). 25759019
SMO W281C basal cell carcinoma resistant Vismodegib Preclinical Actionable In a preclinical study, a transformed cell line expressing SMO W281C was resistant to Erivedge (vismodegib) as demonstrated by elevated gene expression levels of GLI1 resulting in increased signaling of the hedgehog pathway (PMID: 25759020). 25759020
SMO W281C Advanced Solid Tumor decreased response Taladegib Preclinical Actionable In a preclinical study, primary cerebellar granule neuron precursor cells over expressing SMO W281C on the background of PTCH1 and TP53 deletion demonstrated reduced response to LY2940680 induced growth inhibition in cell culture (PMID: 25759019). 25759019
Clinical Trial Phase Therapies Title Recruitment Status